[HTML][HTML] Dishevelled proteins lead to two signaling pathways: regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells
L Li, H Yuan, W Xie, J Mao, AM Caruso… - Journal of Biological …, 1999 - ASBMB
Dishevelled (Dsh/Dvl) proteins are known to mediate Wnt signaling by up-regulating β-
catenin levels and stimulating T cell factor (TCF)/LEF-1-dependent transcription. We have
identified a new Dvl-mediated signaling pathway in that mouse Dvl proteins, when
expressed in COS-7 cells, stimulate c-Jun-dependent transcription activity and the kinase
activity of the c-Jun N-terminal kinase (JNK). The DEP domain of Dvl1 is essential for JNK
activation. By contrast, all three conserved domains of Dvl, including DIX, PDZ, and DEP, are …
catenin levels and stimulating T cell factor (TCF)/LEF-1-dependent transcription. We have
identified a new Dvl-mediated signaling pathway in that mouse Dvl proteins, when
expressed in COS-7 cells, stimulate c-Jun-dependent transcription activity and the kinase
activity of the c-Jun N-terminal kinase (JNK). The DEP domain of Dvl1 is essential for JNK
activation. By contrast, all three conserved domains of Dvl, including DIX, PDZ, and DEP, are …