Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N …
K Takebayashi, Y Sasai, Y Sakai, T Watanabe… - Journal of Biological …, 1994 - ASBMB
HES-1 is a mammalian helix-loop-helix factor structurally related to the Drosophila hairy and
Enhancer of split proteins. It binds more preferentially to the N box (CACNAG) than to the E
box (CANNTG) and acts as a negative regulator. In this study, we have isolated and
characterized the mouse HES-1 gene. This gene consists of four exons, and the positions of
introns are well conserved when compared with those of the Drosophila hairy gene, except
for the third intron. Southern blot and interspecies backcross analyses suggest that the …
Enhancer of split proteins. It binds more preferentially to the N box (CACNAG) than to the E
box (CANNTG) and acts as a negative regulator. In this study, we have isolated and
characterized the mouse HES-1 gene. This gene consists of four exons, and the positions of
introns are well conserved when compared with those of the Drosophila hairy gene, except
for the third intron. Southern blot and interspecies backcross analyses suggest that the …