Objective To review the recent evidence that has emerged supporting the role of bone as an
endocrine organ. Methods This review will detail how bone has emerged as a bona fide
endocrine “gland,” and with that, the potential therapeutic implications that could be realized
for this hormone-secreting tissue by detailing the evidence in the literature supporting this
view. Results The recent advances point to the skeleton as an endocrine organ that
modulates glucose tolerance and testosterone production by secretion of the bone-specific …