Sirtuins, cell senescence, and vascular aging
Y Kida, MS Goligorsky - Canadian Journal of Cardiology, 2016 - Elsevier
The sirtuins (SIRTs) constitute a class of proteins with nicotinamide adenine dinucleotide-
dependent deacetylase or adenosine diphosphate-ribosyltransferase activity. Seven SIRT
family members have been identified in mammals, from SIRT1, the best studied for its role in
vascular aging, to SIRT7. SIRT1 and SIRT2 are localized in the nucleus and cytoplasm.
SIRT3, SIRT4, and SIRT5 are mitochondrial, and SIRT6 and SIRT7 are nuclear. Extensive
studies have clearly revealed that SIRT proteins regulate diverse cell functions and …
dependent deacetylase or adenosine diphosphate-ribosyltransferase activity. Seven SIRT
family members have been identified in mammals, from SIRT1, the best studied for its role in
vascular aging, to SIRT7. SIRT1 and SIRT2 are localized in the nucleus and cytoplasm.
SIRT3, SIRT4, and SIRT5 are mitochondrial, and SIRT6 and SIRT7 are nuclear. Extensive
studies have clearly revealed that SIRT proteins regulate diverse cell functions and …