Chronic treatment with PDGF-BB and endothelin-1 synergistically induces vascular hyperplasia and loss of contractility in organ-cultured rat tail artery
T Kida, H Chuma, T Murata, H Yamawaki, S Matsumoto… - Atherosclerosis, 2011 - Elsevier
OBJECTIVE: In this study, we examined the synergistic effects of the two potent pathogenic
factors, platelet-derived growth factor-BB (PDGF-BB) and endothelin-1 (ET-1) to induce
vascular hyperplasia using ex vivo organ-culture system. METHODS AND RESULTS: In
organ-cultured rat tail arteries, concomitant treatment with 100ng/ml PDGF-BB and 300nM
ET-1 for 4 days induced medial hyperplasia with increased smooth muscle cell proliferation.
Concomitant treatment with PDGF-BB (10–300nM) and ET-1 (30nM–1μM) dose …
factors, platelet-derived growth factor-BB (PDGF-BB) and endothelin-1 (ET-1) to induce
vascular hyperplasia using ex vivo organ-culture system. METHODS AND RESULTS: In
organ-cultured rat tail arteries, concomitant treatment with 100ng/ml PDGF-BB and 300nM
ET-1 for 4 days induced medial hyperplasia with increased smooth muscle cell proliferation.
Concomitant treatment with PDGF-BB (10–300nM) and ET-1 (30nM–1μM) dose …