What DKKtates where to metastasize
W Zheng, JW Pollard - Nature Cell Biology, 2017 - nature.com
W Zheng, JW Pollard
Nature Cell Biology, 2017•nature.comCancer cells preferentially metastasize to certain organs. A study in mouse models of breast
cancer shows that the DKK1 negative regulator of WNT signalling inhibits tropism to the
lung, but enhances tropism to the bone due to the differential regulation of canonical and
non-canonical WNT signalling in the two microenvironments.
cancer shows that the DKK1 negative regulator of WNT signalling inhibits tropism to the
lung, but enhances tropism to the bone due to the differential regulation of canonical and
non-canonical WNT signalling in the two microenvironments.
Cancer cells preferentially metastasize to certain organs. A study in mouse models of breast cancer shows that the DKK1 negative regulator of WNT signalling inhibits tropism to the lung, but enhances tropism to the bone due to the differential regulation of canonical and non-canonical WNT signalling in the two microenvironments.
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