Development of adrenal cortex zonation
Y Xing, AM Lerario, W Rainey… - … and Metabolism Clinics, 2015 - endo.theclinics.com
Origin of the adrenogonadal primordium The adrenal glands develop from 2 separate
embryologic tissues: the medulla is derived from neural crest cells originating in proximity to
the dorsal aorta, whereas the cortex develops from the intermediate mesoderm. 1 The
appearance of the adrenal gland in the form of the adrenogonadal primordium (AGP) at 28
to 30 days postconception (dpc) in humans (embryonic day [E] 9.0 in mice) is marked by the
expression of steroidogenic factor 1 (SF1; NR5A1), a nuclear receptor essential for adrenal …
embryologic tissues: the medulla is derived from neural crest cells originating in proximity to
the dorsal aorta, whereas the cortex develops from the intermediate mesoderm. 1 The
appearance of the adrenal gland in the form of the adrenogonadal primordium (AGP) at 28
to 30 days postconception (dpc) in humans (embryonic day [E] 9.0 in mice) is marked by the
expression of steroidogenic factor 1 (SF1; NR5A1), a nuclear receptor essential for adrenal …