[HTML][HTML] Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor
R Bussiere, A Lacampagne, S Reiken, X Liu… - Journal of Biological …, 2017 - ASBMB
Alteration of ryanodine receptor (RyR)-mediated calcium (Ca 2+) signaling has been
reported in Alzheimer disease (AD) models. However, the molecular mechanisms
underlying altered RyR-mediated intracellular Ca 2+ release in AD remain to be fully
elucidated. We report here that RyR2 undergoes post-translational modifications
(phosphorylation, oxidation, and nitrosylation) in SH-SY5Y neuroblastoma cells expressing
the β-amyloid precursor protein (βAPP) harboring the familial double Swedish mutations …
reported in Alzheimer disease (AD) models. However, the molecular mechanisms
underlying altered RyR-mediated intracellular Ca 2+ release in AD remain to be fully
elucidated. We report here that RyR2 undergoes post-translational modifications
(phosphorylation, oxidation, and nitrosylation) in SH-SY5Y neuroblastoma cells expressing
the β-amyloid precursor protein (βAPP) harboring the familial double Swedish mutations …
