The calcium release channel of sarcoplasmic reticulum is modulated by FK-506-binding protein. Dissociation and reconstitution of FKBP-12 to the calcium release …
AP Timerman, E Ogunbumni, E Freund… - Journal of Biological …, 1993 - ASBMB
The ryanodine receptor/calcium release channel (CRC) of rabbit skeletal muscle terminal
cisternae (TC) of sarcoplasmic reticulum (SR) has been found to be tightly associated with
FK-506 binding protein (FKBP-12), the cytosolic receptor (immunophilin) for the
immunosuppressant drug FK-506 (Jayaraman, T., Brillantes, AM, Timerman, AP, Fleischer,
S., Erdjument-Bromage, H., Tempst, P., and Marks, A.(1992) J. Biol. Chem. 267, 9474-9477).
In this study, a procedure is described to dissociate FKBP from TC and reconstitute human …
cisternae (TC) of sarcoplasmic reticulum (SR) has been found to be tightly associated with
FK-506 binding protein (FKBP-12), the cytosolic receptor (immunophilin) for the
immunosuppressant drug FK-506 (Jayaraman, T., Brillantes, AM, Timerman, AP, Fleischer,
S., Erdjument-Bromage, H., Tempst, P., and Marks, A.(1992) J. Biol. Chem. 267, 9474-9477).
In this study, a procedure is described to dissociate FKBP from TC and reconstitute human …
