Dendritic cells: functional aspects of glycosylation and lectins
A Erbacher, F Gieseke, R Handgretinger, I Müller - Human immunology, 2009 - Elsevier
Dendritic cells (DC) direct immune responses either toward tolerance to a presented antigen
or toward inflammatory reactions of effector cells. Many crucial cytokines and cell surface
proteins have been identified in this process using gene expression profiling. However, it is
becoming evident that important steps involve carbohydrate–protein interactions, which
cannot be anticipated by gene expression profiling in most cases. These contacts are crucial
for the uptake of certain antigens, migration, and homing, but also for infection by viruses. On …
or toward inflammatory reactions of effector cells. Many crucial cytokines and cell surface
proteins have been identified in this process using gene expression profiling. However, it is
becoming evident that important steps involve carbohydrate–protein interactions, which
cannot be anticipated by gene expression profiling in most cases. These contacts are crucial
for the uptake of certain antigens, migration, and homing, but also for infection by viruses. On …
