Spike—nucleocapsid interaction in Semliki Forest virus reconstructed using network antibodies
Nature, 1988•nature.com
Using in vitro immunization, we have reconstructed three consecutive steps of an idiotype
network to show that the nucleocapsid of Semliki Forest virus contains a specific" receptor"
for the cytoplasmic tail of the E2 spike glycoprotein. This interaction could be the basis for
the highly selective inclusion of viral glycoproteins—and exclusion of host cell surface
proteins—during virus budding. 5
network to show that the nucleocapsid of Semliki Forest virus contains a specific" receptor"
for the cytoplasmic tail of the E2 spike glycoprotein. This interaction could be the basis for
the highly selective inclusion of viral glycoproteins—and exclusion of host cell surface
proteins—during virus budding. 5
Abstract
Using in vitro immunization, we have reconstructed three consecutive steps of an idiotype network to show that the nucleocapsid of Semliki Forest virus contains a specific "receptor" for the cytoplasmic tail of the E2 spike glycoprotein. This interaction could be the basis for the highly selective inclusion of viral glycoproteins—and exclusion of host cell surface proteins—during virus budding.5
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