Invasion into surrounding brain tissue is a fundamental feature of gliomas and the major
reason for treatment failure. The process of brain invasion in gliomas is not well understood.
Differences in gene expression and/or gene products between invading and noninvading
glioma cells may identify potential targets for new therapies. To look for genes associated
with glioma invasion, we first employed Affymetrix microarray Genechip® technology to
identify genes differentially expressed in migrating glioma cells in vitro and in invading …