Immune response in patients with newly diagnosed glioblastoma multiforme treated with intranodal autologous tumor lysate-dendritic cell vaccination after radiation …
CE Fadul, JL Fisher, TH Hampton… - Journal of …, 2011 - journals.lww.com
Patients with glioblastoma multiforme (GBM) are profoundly immunosuppressed and may
benefit from restoration of an antitumor immune response in combination with conventional
radiation therapy and temozolomide (TMZ). The optimal strategies to evaluate clinically
relevant immune responses to treatment have yet to be determined. The primary objective of
our study was to determine immunologic response to cervical intranodal vaccination with
autologous tumor lysate-loaded dendritic cells (DCs) in patients with GBM after radiation …
benefit from restoration of an antitumor immune response in combination with conventional
radiation therapy and temozolomide (TMZ). The optimal strategies to evaluate clinically
relevant immune responses to treatment have yet to be determined. The primary objective of
our study was to determine immunologic response to cervical intranodal vaccination with
autologous tumor lysate-loaded dendritic cells (DCs) in patients with GBM after radiation …
