PGC-1α protects from notch-induced kidney fibrosis development
Kidney fibrosis is the histologic manifestation of CKD. Sustained activation of developmental
pathways, such as Notch, in tubule epithelial cells has been shown to have a key role in
fibrosis development. The molecular mechanism of Notch-induced fibrosis, however,
remains poorly understood. Here, we show that, that expression of peroxisomal proliferation
g-coactivator (PGC-1α) and fatty acid oxidation-related genes are lower in mice expressing
active Notch1 in tubular epithelial cells (Pax8-rtTA/ICN1) compared to littermate controls …
pathways, such as Notch, in tubule epithelial cells has been shown to have a key role in
fibrosis development. The molecular mechanism of Notch-induced fibrosis, however,
remains poorly understood. Here, we show that, that expression of peroxisomal proliferation
g-coactivator (PGC-1α) and fatty acid oxidation-related genes are lower in mice expressing
active Notch1 in tubular epithelial cells (Pax8-rtTA/ICN1) compared to littermate controls …