Serum 6-bromotryptophan levels identified as a risk factor for CKD progression
A Tin, G Nadkarni, AM Evans, CA Winkler… - Journal of the …, 2018 - journals.lww.com
Background Metabolite levels reflect physiologic homeostasis and may serve as biomarkers
of disease progression. Identifying metabolites associated with APOL1 risk alleles—genetic
variants associated with CKD risk commonly present in persons of African descent—may
reveal novel markers of CKD progression relevant to other populations. Methods We
evaluated associations between the number of APOL1 risk alleles and 760 serum
metabolites identified via untargeted profiling in participants of the African American Study of …
of disease progression. Identifying metabolites associated with APOL1 risk alleles—genetic
variants associated with CKD risk commonly present in persons of African descent—may
reveal novel markers of CKD progression relevant to other populations. Methods We
evaluated associations between the number of APOL1 risk alleles and 760 serum
metabolites identified via untargeted profiling in participants of the African American Study of …
