Glomerular hyperfiltration in diabetes: mechanisms, clinical significance, and treatment
L Tonneijck, MHA Muskiet, MM Smits… - Journal of the …, 2017 - journals.lww.com
An absolute, supraphysiologic elevation in GFR is observed early in the natural history in
10%–67% and 6%–73% of patients with type 1 and type 2 diabetes, respectively. Moreover,
at the single-nephron level, diabetes-related renal hemodynamic alterations—as an
adaptation to reduction in functional nephron mass and/or in response to prevailing
metabolic and (neuro) hormonal stimuli—increase glomerular hydraulic pressure and
transcapillary convective flux of ultrafiltrate and macromolecules. This phenomenon, known …
10%–67% and 6%–73% of patients with type 1 and type 2 diabetes, respectively. Moreover,
at the single-nephron level, diabetes-related renal hemodynamic alterations—as an
adaptation to reduction in functional nephron mass and/or in response to prevailing
metabolic and (neuro) hormonal stimuli—increase glomerular hydraulic pressure and
transcapillary convective flux of ultrafiltrate and macromolecules. This phenomenon, known …
