The germinal center (GC) reaction is the basis of T-dependent humoral immunity against
foreign pathogens and the ultimate expression of the adaptive immune response. GCs
represent a unique collaboration between proliferating antigen-specific B cells, T follicular
helper cells, and the specialized follicular dendritic cells that constitutively occupy the central
follicular zones of secondary lymphoid organs. The primary function of GCs is to produce the
high-affinity antibody-secreting plasma cells and memory B cells that ensure sustained …