[HTML][HTML] Characterization of the structure and intermolecular interactions between the connexin40 and connexin43 carboxyl-terminal and cytoplasmic loop domains
D Bouvier, G Spagnol, S Chenavas, F Kieken… - Journal of biological …, 2009 - ASBMB
Gap junctions are intercellular channels that allow the passage of ions, small molecules,
and second messengers that are essential for the coordination of cellular function. They are
formed by two hemichannels, each constituted by the oligomerization of six connexins (Cx).
Among the 21 different human Cx isoforms, studies have suggested that in the heart, Cx40
and Cx43 can oligomerize to form heteromeric hemichannels. The mechanism of
heteromeric channel regulation has not been clearly defined. Tissue ischemia leads to …
and second messengers that are essential for the coordination of cellular function. They are
formed by two hemichannels, each constituted by the oligomerization of six connexins (Cx).
Among the 21 different human Cx isoforms, studies have suggested that in the heart, Cx40
and Cx43 can oligomerize to form heteromeric hemichannels. The mechanism of
heteromeric channel regulation has not been clearly defined. Tissue ischemia leads to …
