[HTML][HTML] Connexin 43 hemichannels contribute to cytoplasmic Ca2+ oscillations by providing a bimodal Ca2+-dependent Ca2+ entry pathway
M De Bock, N Wang, M Bol, E Decrock… - Journal of Biological …, 2012 - ASBMB
Many cellular functions are driven by changes in the intracellular Ca 2+ concentration ([Ca
2+] i) that are highly organized in time and space. Ca 2+ oscillations are particularly
important in this respect and are based on positive and negative [Ca 2+] i feedback on
inositol 1, 4, 5-trisphosphate receptors (InsP 3 Rs). Connexin hemichannels are Ca 2+-
permeable plasma membrane channels that are also controlled by [Ca 2+] i. We aimed to
investigate how hemichannels may contribute to Ca 2+ oscillations. Madin-Darby canine …
2+] i) that are highly organized in time and space. Ca 2+ oscillations are particularly
important in this respect and are based on positive and negative [Ca 2+] i feedback on
inositol 1, 4, 5-trisphosphate receptors (InsP 3 Rs). Connexin hemichannels are Ca 2+-
permeable plasma membrane channels that are also controlled by [Ca 2+] i. We aimed to
investigate how hemichannels may contribute to Ca 2+ oscillations. Madin-Darby canine …
