Regulation of connexin43 function and expression by tyrosine kinase 2
H Li, G Spagnol, L Zheng, KL Stauch… - Journal of Biological …, 2016 - ASBMB
Connexin43 (Cx43) assembly and degradation, the regulation of electrical and metabolic
coupling, as well as modulating the interaction with other proteins, involve phosphorylation.
Here, we identified and characterized the biological significance of a novel tyrosine kinase
that phosphorylates Cx43, tyrosine kinase 2 (Tyk2). Activation of Tyk2 led to a decrease in
Cx43 gap junction communication by increasing the turnover rate of Cx43 from the plasma
membrane. Tyk2 directly phosphorylated Cx43 residues Tyr-247 and Tyr-265, leading to …
coupling, as well as modulating the interaction with other proteins, involve phosphorylation.
Here, we identified and characterized the biological significance of a novel tyrosine kinase
that phosphorylates Cx43, tyrosine kinase 2 (Tyk2). Activation of Tyk2 led to a decrease in
Cx43 gap junction communication by increasing the turnover rate of Cx43 from the plasma
membrane. Tyk2 directly phosphorylated Cx43 residues Tyr-247 and Tyr-265, leading to …
