Nephron-specific deletion of circadian clock gene Bmal1 alters the plasma and renal metabolome and impairs drug disposition
S Nikolaeva, C Ansermet, G Centeno… - Journal of the …, 2016 - journals.lww.com
The circadian clock controls a wide variety of metabolic and homeostatic processes in a
number of tissues, including the kidney. However, the role of the renal circadian clocks
remains largely unknown. To address this question, we performed a combined functional,
transcriptomic, and metabolomic analysis in mice with inducible conditional knockout (cKO)
of BMAL1, which is critically involved in the circadian clock system, in renal tubular cells
(Bmal1 lox/lox/Pax8-rtTA/LC1 mice). Induction of cKO in adult mice did not produce obvious …
number of tissues, including the kidney. However, the role of the renal circadian clocks
remains largely unknown. To address this question, we performed a combined functional,
transcriptomic, and metabolomic analysis in mice with inducible conditional knockout (cKO)
of BMAL1, which is critically involved in the circadian clock system, in renal tubular cells
(Bmal1 lox/lox/Pax8-rtTA/LC1 mice). Induction of cKO in adult mice did not produce obvious …
