Establishment of the LNCaP cell line–the dawn of an era for prostate cancer research
C Abate-Shen, F Nunes de Almeida - Cancer research, 2022 - AACR
Cancer research, 2022•AACR
Among the relatively few established human prostate cancer cell lines, LNCaP cells are
unique in their ability to model key stages of prostate cancer progression. Analyses of
LNCaP cells and their derivatives have been invaluable for elucidating important
translational aspects of prostate tumorigenesis, metastasis, and drug response, particularly
in the context of androgen receptor signaling. Here, we present major highlights from a
wealth of literature that has exploited LNCaP cells and their derivatives to inform on prostate …
unique in their ability to model key stages of prostate cancer progression. Analyses of
LNCaP cells and their derivatives have been invaluable for elucidating important
translational aspects of prostate tumorigenesis, metastasis, and drug response, particularly
in the context of androgen receptor signaling. Here, we present major highlights from a
wealth of literature that has exploited LNCaP cells and their derivatives to inform on prostate …
Abstract
Among the relatively few established human prostate cancer cell lines, LNCaP cells are unique in their ability to model key stages of prostate cancer progression. Analyses of LNCaP cells and their derivatives have been invaluable for elucidating important translational aspects of prostate tumorigenesis, metastasis, and drug response, particularly in the context of androgen receptor signaling. Here, we present major highlights from a wealth of literature that has exploited LNCaP cells and their derivatives to inform on prostate cancer progression and androgen response for improving the treatment of patients with prostate cancer.
See related article by Horoszewicz and colleagues, Cancer Res 1983;43:1809–18
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