Organoid sensitivity correlates with therapeutic response in patients with pancreatic cancer
Clinical Cancer Research, 2022•AACR
Purpose: Pancreatic ductal adenocarcinoma (PDAC) remains a significant health issue. For
most patients, there are no options for targeted therapy, and existing treatments are limited
by toxicity. The HOPE trial (Harnessing Organoids for PErsonalized Therapy) was a pilot
feasibility trial aiming to prospectively generate patient-derived organoids (PDO) from
patients with PDAC and test their drug sensitivity and correlation with clinical outcomes.
Experimental Design: PDOs were established from a heterogeneous population of patients …
most patients, there are no options for targeted therapy, and existing treatments are limited
by toxicity. The HOPE trial (Harnessing Organoids for PErsonalized Therapy) was a pilot
feasibility trial aiming to prospectively generate patient-derived organoids (PDO) from
patients with PDAC and test their drug sensitivity and correlation with clinical outcomes.
Experimental Design: PDOs were established from a heterogeneous population of patients …
Purpose
Pancreatic ductal adenocarcinoma (PDAC) remains a significant health issue. For most patients, there are no options for targeted therapy, and existing treatments are limited by toxicity. The HOPE trial (Harnessing Organoids for PErsonalized Therapy) was a pilot feasibility trial aiming to prospectively generate patient-derived organoids (PDO) from patients with PDAC and test their drug sensitivity and correlation with clinical outcomes.
Experimental Design
PDOs were established from a heterogeneous population of patients with PDAC including both basal and classical PDAC subtypes.
Results
A method for classifying PDOs as sensitive or resistant to chemotherapy regimens was developed to predict the clinical outcome of patients. Drug sensitivity testing on PDOs correlated with clinical responses to treatment in individual patients.
Conclusions
These data support the investigation of PDOs to guide treatment in prospective interventional trials in PDAC.
AACR
