Neurons are polarized cells, with dendrites and axons that require different complements of
membrane proteins to fulfill their specialized functions. Membrane proteins are synthesized
in the somatodendritic domain and delivered to their target membranes via long-range
vesicle transport. Most anterograde vesicle transport is mediated by kinesin motors, but it is
unclear how kinesins are targeted to axons or dendrites. Two main models have been
proposed to explain kinesin selectivity. In the smart motor model, kinesin selectivity is …