α-Synuclein oligomers impair neuronal microtubule-kinesin interplay
I Prots, V Veber, S Brey, S Campioni, K Buder… - Journal of Biological …, 2013 - ASBMB
Early α-synuclein (α-Syn)-induced alterations are neurite pathologies resulting in Lewy
neurites. α-Syn oligomers are a toxic species in synucleinopathies and are suspected to
cause neuritic pathology. To investigate how α-Syn oligomers may be linked to aberrant
neurite pathology, we modeled different stages of α-Syn aggregation in vitro and
investigated the interplay of α-Syn aggregates with proteins involved in axonal transport.
The interaction of wild type α-Syn (WTS) and α-Syn variants (E57K, A30P, and aSyn (30 …
neurites. α-Syn oligomers are a toxic species in synucleinopathies and are suspected to
cause neuritic pathology. To investigate how α-Syn oligomers may be linked to aberrant
neurite pathology, we modeled different stages of α-Syn aggregation in vitro and
investigated the interplay of α-Syn aggregates with proteins involved in axonal transport.
The interaction of wild type α-Syn (WTS) and α-Syn variants (E57K, A30P, and aSyn (30 …
