[HTML][HTML] Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation
CL Yu, SJ Burakoff - Journal of Biological Chemistry, 1997 - ASBMB
Interleukin-2 (IL-2) activates the receptor-associated Janus family tyrosine kinases, Jak1 and
Jak3, which in turn phosphorylate and activate specific STAT proteins (signal transducers
and activators of transcription), such as STAT5. Activation of Jak and STAT proteins by IL-2
is transient and the mechanism for the subsequent down-regulation of their activity is largely
unknown. We report here that IL-2-induced DNA-binding activity and tyrosine
phosphorylation of STAT5 are stabilized by a proteasome inhibitor MG132; however, no …
Jak3, which in turn phosphorylate and activate specific STAT proteins (signal transducers
and activators of transcription), such as STAT5. Activation of Jak and STAT proteins by IL-2
is transient and the mechanism for the subsequent down-regulation of their activity is largely
unknown. We report here that IL-2-induced DNA-binding activity and tyrosine
phosphorylation of STAT5 are stabilized by a proteasome inhibitor MG132; however, no …