[HTML][HTML] Hormetic endoplasmic reticulum stress in hematopoietic stem cells
LL Luchsinger - Current opinion in hematology, 2021 - journals.lww.com
LL Luchsinger
Current opinion in hematology, 2021•journals.lww.comThe maintenance of HSCs requires a dose-dependent simulation of ER stress responses
that involves persistent, low-dose UPR. Unraveling the complexity of this signaling node
may elucidate mechanisms related to regeneration of HSCs that can be harnessed to
expand HSCs for cellular therapeutics ex vivo and transplantation in vivo.
that involves persistent, low-dose UPR. Unraveling the complexity of this signaling node
may elucidate mechanisms related to regeneration of HSCs that can be harnessed to
expand HSCs for cellular therapeutics ex vivo and transplantation in vivo.
Summary
The maintenance of HSCs requires a dose-dependent simulation of ER stress responses that involves persistent, low-dose UPR. Unraveling the complexity of this signaling node may elucidate mechanisms related to regeneration of HSCs that can be harnessed to expand HSCs for cellular therapeutics ex vivo and transplantation in vivo.
Lippincott Williams & Wilkins