[HTML][HTML] Combination of correctors rescue ΔF508-CFTR by reducing its association with Hsp40 and Hsp27
M Lopes-Pacheco, C Boinot, I Sabirzhanova… - Journal of Biological …, 2015 - ASBMB
Correcting the processing of ΔF508-CFTR, the most common mutation in cystic fibrosis, is
the major goal in the development of new therapies for this disease. Here, we determined
whether ΔF508 could be rescued by a combination of small-molecule correctors, and
identified the mechanism by which correctors rescue the trafficking mutant of cystic fibrosis
transmembrane conductance regulator (CFTR). We transfected COS-7 cells with ΔF508,
created HEK-293 stably expressing ΔF508, and utilized CFBE41o− cell lines stably …
the major goal in the development of new therapies for this disease. Here, we determined
whether ΔF508 could be rescued by a combination of small-molecule correctors, and
identified the mechanism by which correctors rescue the trafficking mutant of cystic fibrosis
transmembrane conductance regulator (CFTR). We transfected COS-7 cells with ΔF508,
created HEK-293 stably expressing ΔF508, and utilized CFBE41o− cell lines stably …