The mitochondria-bound adapter MAVS participates in IFN induction by recruitment of
downstream partners such as members of the TRAF family, leading to activation of NF-κB,
and the IRF3 pathways. A yeast two-hybrid search for MAVS-interacting proteins yielded the
Polo-box domain (PBD) of the mitotic Polo-like kinase PLK1. We showed that PBD
associates with two different domains of MAVS in both dependent and independent
phosphorylation events. The phosphodependent association requires the phosphopeptide …