Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness

V Kari, WY Mansour, SK Raul, SJ Baumgart, A Mund… - EMBO …, 2018 - embopress.org
V Kari, WY Mansour, SK Raul, SJ Baumgart, A Mund, M Grade, H Sirma, R Simon, H Will…
EMBO reports, 2018embopress.org
The authors declare that they used the same samples on different gels in Fig EV5B, but they
state that they used a different loading order for cH2AX than on the other gels, and spliced
the gel to match the loading order of the other gels. The authors correct the legend for Fig
EV5B to state:“PC3 cells were pretreated with DMSO, mirin (50 lM), or veliparib (20 lM,
PARPi) for 1 h prior to NCS treatment for 2, 4, or 6 h. Chromatin fractions were analyzed by
Western blot for the recruitment of CHD1, CtIP, RAD51, and cH2AX, which was rearranged …
The authors declare that they used the same samples on different gels in Fig EV5B, but they state that they used a different loading order for cH2AX than on the other gels, and spliced the gel to match the loading order of the other gels. The authors correct the legend for Fig EV5B to state:“PC3 cells were pretreated with DMSO, mirin (50 lM), or veliparib (20 lM, PARPi) for 1 h prior to NCS treatment for 2, 4, or 6 h. Chromatin fractions were analyzed by Western blot for the recruitment of CHD1, CtIP, RAD51, and cH2AX, which was rearranged to match the loading order of the other gels”. The corrected figure is shown here. The cut bands are highlighted in a box.
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