Recent advances in hyaluronic acid hydrogels for biomedical applications
CB Highley, GD Prestwich, JA Burdick - Current opinion in biotechnology, 2016 - Elsevier
CB Highley, GD Prestwich, JA Burdick
Current opinion in biotechnology, 2016•ElsevierHighlights•New modifications to hyaluronic acid (HA) enable both covalent crosslinking and
supramolecular assembly.•Composite HA hydrogels permit controlled drug delivery and
mechanical toughness.•Processing such as electrospinning, 3D printing, and
photopatterning allow the formation of complex structures in HA hydrogels.•HA hydrogels
are engineered to influence the fate of encapsulated or endogenous cells.•HA hydrogels
continue to advance basic science and translational biomedical research.Hyaluronic acid …
supramolecular assembly.•Composite HA hydrogels permit controlled drug delivery and
mechanical toughness.•Processing such as electrospinning, 3D printing, and
photopatterning allow the formation of complex structures in HA hydrogels.•HA hydrogels
are engineered to influence the fate of encapsulated or endogenous cells.•HA hydrogels
continue to advance basic science and translational biomedical research.Hyaluronic acid …
Highlights
- New modifications to hyaluronic acid (HA) enable both covalent crosslinking and supramolecular assembly.
- Composite HA hydrogels permit controlled drug delivery and mechanical toughness.
- Processing such as electrospinning, 3D printing, and photopatterning allow the formation of complex structures in HA hydrogels.
- HA hydrogels are engineered to influence the fate of encapsulated or endogenous cells.
- HA hydrogels continue to advance basic science and translational biomedical research.
Hyaluronic acid (HA) is widely used in the design of engineered hydrogels, due to its biofunctionality, as well as numerous sites for modification with reactive groups. There are now widespread examples of modified HA macromers that form either covalent or physical hydrogels through crosslinking reactions such as with click chemistry or supramolecular assemblies of guest-host pairs. HA hydrogels range from relatively static matrices to those that exhibit spatiotemporally dynamic properties through external triggers like light. Such hydrogels are being explored for the culture of cells in vitro, as carriers for cells in vivo, or to deliver therapeutics, including in an environmentally responsive manner. The future will bring new examples of HA hydrogels due to the synthetic diversity of HA.
Elsevier