Expression of Yes-associated protein in common solid tumors
The Hippo signaling pathway is a highly conserved potent regulator of cell growth, division,
and apoptosis. Yes-associated protein (YAP), the nuclear effector of the Hippo pathway, is a
highly conserved component of this pathway in mammalian systems. In humans,
amplification of the chromosome region containing the YAP gene (11q22) has been
reported in several tumor types. This study was performed to determine if YAP expression
was present in 4 common types of malignant tumors that have the highest lifetime risk of …
and apoptosis. Yes-associated protein (YAP), the nuclear effector of the Hippo pathway, is a
highly conserved component of this pathway in mammalian systems. In humans,
amplification of the chromosome region containing the YAP gene (11q22) has been
reported in several tumor types. This study was performed to determine if YAP expression
was present in 4 common types of malignant tumors that have the highest lifetime risk of …