Expression of cancer stem cell markers is prognostic in metastatic gastroesophageal adenocarcinoma
D Brungs, A Lochhead, A Iyer, M Illemann, P Colligan… - Pathology, 2019 - Elsevier
Gastroesophageal adenocarcinoma is a common and highly lethal malignancy. Cancer
stem cells (CSCs) have a key role in the development and progression of metastatic
disease. While expression of CSC markers CD44, CD133 and aldehyde dehydrogenase 1
(ALDH1) in locoregional gastroesophageal cancer is known to be associated with poorer
clinical outcomes, the significance of CSC marker expression in distal metastatic disease is
unknown. We investigated the clinicopathological and prognostic associations of the CSC …
stem cells (CSCs) have a key role in the development and progression of metastatic
disease. While expression of CSC markers CD44, CD133 and aldehyde dehydrogenase 1
(ALDH1) in locoregional gastroesophageal cancer is known to be associated with poorer
clinical outcomes, the significance of CSC marker expression in distal metastatic disease is
unknown. We investigated the clinicopathological and prognostic associations of the CSC …