Organoids as an in vitro model of human development and disease
A Fatehullah, SH Tan, N Barker - Nature cell biology, 2016 - nature.com
A Fatehullah, SH Tan, N Barker
Nature cell biology, 2016•nature.comThe in vitro organoid model is a major technological breakthrough that has already been
established as an essential tool in many basic biology and clinical applications. This near-
physiological 3D model facilitates an accurate study of a range of in vivo biological
processes including tissue renewal, stem cell/niche functions and tissue responses to drugs,
mutation or damage. In this Review, we discuss the current achievements, challenges and
potential applications of this technique.
established as an essential tool in many basic biology and clinical applications. This near-
physiological 3D model facilitates an accurate study of a range of in vivo biological
processes including tissue renewal, stem cell/niche functions and tissue responses to drugs,
mutation or damage. In this Review, we discuss the current achievements, challenges and
potential applications of this technique.
Abstract
The in vitro organoid model is a major technological breakthrough that has already been established as an essential tool in many basic biology and clinical applications. This near-physiological 3D model facilitates an accurate study of a range of in vivo biological processes including tissue renewal, stem cell/niche functions and tissue responses to drugs, mutation or damage. In this Review, we discuss the current achievements, challenges and potential applications of this technique.
nature.com