BCG-induced formation of neutrophil extracellular traps play an important role in bladder cancer treatment
K Liu, E Sun, M Lei, L Li, J Gao, X Nian, L Wang - Clinical immunology, 2019 - Elsevier
Abstract Bacillus Calmette-Guerin (BCG) is one of the most effective treatments for bladder
cancer. Little attention has been paid to the possible role of neutrophils in BCG
immunotherapy. In this study, we examined neutrophil extracellular traps (NETs) formation
induced by BCG stimulation, and found that BCG-induced NETs exerted cytotoxicity,
induced apoptosis and cell-cycle arrest, and inhibited migration in bladder tumor cells. BCG-
activated tumor cells but not non-activated ones elicited NETs formation, in which IL-8 and …
cancer. Little attention has been paid to the possible role of neutrophils in BCG
immunotherapy. In this study, we examined neutrophil extracellular traps (NETs) formation
induced by BCG stimulation, and found that BCG-induced NETs exerted cytotoxicity,
induced apoptosis and cell-cycle arrest, and inhibited migration in bladder tumor cells. BCG-
activated tumor cells but not non-activated ones elicited NETs formation, in which IL-8 and …
