[HTML][HTML] TRIM56 is an essential component of the TLR3 antiviral signaling pathway
Members of the tripartite motif (TRIM) proteins are being recognized as important regulators
of host innate immunity. However, specific TRIMs that contribute to TLR3-mediated antiviral
defense have not been identified. We show here that TRIM56 is a positive regulator of TLR3
signaling. Overexpression of TRIM56 substantially potentiated extracellular dsRNA-induced
expression of interferon (IFN)-β and interferon-stimulated genes (ISGs), while knockdown of
TRIM56 greatly impaired activation of IRF3, induction of IFN-β and ISGs, and establishment …
of host innate immunity. However, specific TRIMs that contribute to TLR3-mediated antiviral
defense have not been identified. We show here that TRIM56 is a positive regulator of TLR3
signaling. Overexpression of TRIM56 substantially potentiated extracellular dsRNA-induced
expression of interferon (IFN)-β and interferon-stimulated genes (ISGs), while knockdown of
TRIM56 greatly impaired activation of IRF3, induction of IFN-β and ISGs, and establishment …